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  • Antibiotic

    INDICATIONS:
    Contraindicated for the following infections due to fosfomycin-sensitive bacteria such as Pseudomonas aeruginosa, Proteus vulgaris, Serratia marcescens and Staphylococus aureus and Escherichia coli strains resistant to many drugs: sepsis, bronchitis, bronchitis, infectious bronchiectasis, pneumonia, purulent lung disease, purulent pleurisy, peritonitis, pyelonephritis, cystitis, adnexitis, intrauterine infection, bacterial infection pelvic cavity, metritis and bartholin gland inflammation.

    CONTRAINDICATIONS:
    Patients with a history of hypersensitivity to fosfomycin.
    Patients with renal insufficiency have creatinine clearance <5ml / min, nephritis, pyelonephritis or abscess around kidney. DOSAGE AND ADMINISTRATION:
    Intravenous drip infusion:
    The usual daily dose of fosfomycin for intravenous administration is 2-4 g (content); IV intravenous drip. The above dose is divided into 2 doses. Each dose is dissolved in 100-500ml of infusion, the infusion time is from 1-2 hours.

    Intravenous injection:
    – The daily dose is equal to the intravenous drip but must be divided into 2-4 doses. The solvent used to dissolve 1-2g of this preparation is 20ml of water for injection, according to the Japanese Pharmacopoeia or 20ml of 5% glucose solution, according to the Japanese Pharmacopoeia. The duration of intravenous administration must be made in 5 minutes or more.
    * The above dosage may be adjusted according to the patient’s age and the symptoms of severe, mild illness.
    – Children over 12 years old 15): intravenous infusion not exceeding 100-200mg / kg / day
    – People with moderate renal impairment 15) (creatinine clearance ≥ 60 ml / min) do not need to adjust the dose and the interval between doses. Patients with creatinine clearance below 60 ml / min need to extend the interval between doses. The interval between doses depends on creatinine clearance.

    – Hemodialysis patients 15): 2g infusion after each dialysis.
    – Elderly: no dose adjustment is needed.

    STANDARDS: Manufacturer

    STORAGE:
    Storage temperature not exceeding 25 degrees Celsius

    SHELF LIFE:
    36 months. Do not use the medicine after the expiry date stated on the package

    MANUFACTURER:
    MEIJI SEIKA PHARMA CO., LTD.
    2-4-16, Kyobashi, Chuo – ku, Tokyo 104 – 8002, Japan.

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